Good-old Guy Kawasaki has an endearingly cynical but still-so-true guide to How To Get Hired In Silicon Valley. Well worth a read, and just as applicable outside California. Not that I've ever applied for a job in Silicon Valley (yet), but it certainly brought a wry smile to my face.
I've read many CVs and conducted many interviews, and it's amazing just how easy some people make it for you to put their CV on the "no" pile. I know we're now living in the txt-spk generation, but seriously - if you can't spell or punctuate on your CV when you're promoting yourself, how well are you going to promote the company? Interviewers are busy people, and will be looking for any reason to say no - spell well, communicate well, keep it short, and if you get an interview, read and learn from Mr Kawasaki.